David C Griffith Selected Research

vaborbactam

1/2019	Activity of Meropenem-Vaborbactam against Pseudomonas aeruginosa and Acinetobacter baumannii in a Neutropenic Mouse Thigh Infection Model.
1/2019	Pharmacokinetics/Pharmacodynamics of Vaborbactam, a Novel Beta-Lactamase Inhibitor, in Combination with Meropenem.
1/2018	Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae.
1/2018	Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Vaborbactam and Meropenem Alone and in Combination following Single and Multiple Doses in Healthy Adult Subjects.
10/2016	Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects.

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David C Griffith Research Topics

Disease

18	Infections 01/2022 - 01/2003
4	Body Weight (Weight, Body) 10/2020 - 01/2003
4	Cystic Fibrosis (Mucoviscidosis) 06/2011 - 12/2008
3	Pyelonephritis 01/2019 - 01/2003
2	Gram-Negative Bacterial Infections 12/2021 - 01/2020
2	Bacterial Infections (Bacterial Infection) 10/2020 - 01/2010
2	Pneumonia (Pneumonitis) 01/2019 - 01/2003
2	Sepsis (Septicemia) 05/2006 - 01/2003
1	Vomiting 01/2023
1	Exanthema (Rash) 01/2023
1	Nausea 01/2023
1	Urinary Tract Infections (Urinary Tract Infection) 01/2019
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2018
1	Critical Illness (Critically Ill) 01/2018
1	Acute Kidney Injury (Acute Renal Failure) 01/2018
1	Lethargy 10/2016
1	Respiratory Tract Infections (Respiratory Tract Infection) 12/2015
1	Persistent Infection 12/2008
1	Cholera 11/2006

Drug/Important Bio-Agent (IBA)

8	Meropenem (Merrem)FDA LinkGeneric 10/2020 - 12/2015
7	Levofloxacin (Levaquin)FDA Link 01/2020 - 05/2006
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 12/2008
5	meropenem and vaborbactamIBA 01/2019 - 01/2018
5	vaborbactamIBA 01/2019 - 10/2016
5	AerosolsIBA 03/2011 - 12/2008
3	Carbapenems (Carbapenem Antibiotics)IBA 10/2020 - 01/2018
3	Aztreonam FDA LinkGeneric 10/2020 - 09/2009
3	carbapenemaseIBA 01/2019 - 01/2018
3	SolutionsIBA 06/2011 - 09/2009
3	Tobramycin (Nebcin)FDA LinkGeneric 01/2010 - 12/2008
2	biapenem (L 627)IBA 01/2023 - 10/2020
2	Colistin (Coly-Mycin)FDA Link 01/2022 - 01/2018
2	QPX7728IBA 12/2021 - 10/2020
2	Minocycline (Cyclops)FDA LinkGeneric 01/2019 - 01/2018
2	RWJ 54428IBA 01/2008 - 01/2003
1	Polymyxin B (Aerosporin)FDA LinkGeneric 01/2022
1	ProdrugsIBA 12/2021
1	beta Lactam AntibioticsIBA 10/2020
1	Ceftazidime (Fortum)FDA LinkGeneric 10/2020
1	beta-LactamsIBA 10/2020
1	Cefepime (Maxipime)FDA LinkGeneric 10/2020
1	ceftolozaneIBA 10/2020
1	LactamsIBA 01/2020
1	beta-Lactamases (beta-Lactamase)IBA 01/2019
1	Serine (L-Serine)FDA Link 01/2019
1	beta-Lactamase InhibitorsIBA 01/2019
1	CaspasesIBA 01/2018
1	CreatinineIBA 01/2018
1	Caspase 1 (ICE Protease)IBA 01/2018
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2018
1	Caspase 3 (Caspase-3)IBA 01/2018
1	RPX7009IBA 12/2015
1	CytokinesIBA 03/2011
1	Oxygen (Dioxygen)IBA 02/2010
1	Ciprofloxacin (Cipro)FDA LinkGeneric 01/2010
1	Amikacin (A.M.K)FDA LinkGeneric 01/2010
1	AminoglycosidesIBA 01/2010
1	Anti-Infective Agents (Microbicides)IBA 09/2009
1	VaccinesIBA 11/2006
1	Penicillins (Penicillin)FDA Link 01/2003
1	Penicillin G (Benzylpenicillin)FDA LinkGeneric 01/2003
1	Vancomycin FDA LinkGeneric 01/2003
1	Cefotaxime (Kendrick)FDA LinkGeneric 01/2003
1	Cephalosporins (Cephalosporin Antibiotics)IBA 01/2003
1	Ampicillin (Omnipen)FDA LinkGeneric 01/2003

Therapy/Procedure

2	Therapeutics 12/2021 - 01/2008
1	Oral Administration 01/2020
1	Renal Dialysis (Hemodialysis) 01/2018